PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

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Capella university

PSY FPX 6110 Learning Theories in Psychology

Prof. Name

Date

Annotated Bibliography

Davis, A. K., So, S., Lancelotta, R., Barsuglia, J. P., & Griffiths, R. R. (2019). 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety. The American Journal of Drug and Alcohol Abuse, 45(2), 161–169. https://doi.org/10.1080/00952990.2018.1545024 Davis, So, Lancelotta, Barsuglia, and Griffiths (2019) investigated the utilization of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a communal setting, revealing unintended ameliorations in depression and anxiety. The study analyzed self-reported levels of depression and anxiety among individuals consuming 5-MeO-DMT in a group environment characterized by structured dosing, procedures, and support mechanisms. The findings suggested that following the use of 5-MeO-DMT, there were reported improvements in symptoms of depression and anxiety among participants. These improvements were associated with increased spiritual significance and personal meaning attributed to the experience. Duerler, P., Schilbach, L., Stämpfli, P., Vollenweider, F. X., & Preller, K. H. (2020). LSD-induced increases in social adaptation to opinions similar to one’s own are associated with stimulation of serotonin receptors. Scientific Reports, 10(1), 12181. https://doi.org/10.1038/s41598-020-68899-y

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Duerler et al. (2020) investigated the impact of LSD on social adaptation to opinions congruent with one’s own, elucidating the role of serotonin receptors in social influence processing. The double-blind random crossover study involved 24 volunteers who received either a placebo, LSD (100 micrograms), or a 5HT2A receptor antagonist plus LSD (100 micrograms) over three sessions. The results indicated that LSD facilitated social adaptation, particularly when individuals encountered opinions aligned with their own. This effect was correlated with heightened activity in the ventral medial prefrontal cortex during social feedback processing, providing insights into the neuropharmacological mechanisms underlying social cognitive behavior. Forstmann, M., Yudkin, D. A., Prosser, A. M., Heller, S. M., & Crockett, M. J. (2020). Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings. Proceedings of the National Academy of Sciences, 117(5), 2338–2346. https://doi.org/10.1073/pnas.1918477117 Forstmann et al. (2020) examined the mediating roles of transformative experiences and social connectedness in the mood-enhancing effects of psilocybin and other psychedelics in naturalistic settings. The three-year study, comprising 1,225 participants across multiple mass gatherings, employed field studies and questionnaire assessments. The findings suggested that recent psychedelic use was associated with heightened transformative experiences and social connectedness, which in turn mediated improvements in positive mood. This study underscores the potential of psychedelics to induce personal transformation and enhance social cohesion in naturalistic settings, with ethical approval from the Oxford Central Research Ethics Committee.

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology (Oxford), 30(12), 1181–1197. https://doi.org/10.1177/0269881116675513 Griffiths et al. (2016) investigated the effects of psilocybin on depression and anxiety symptoms in cancer patients through a randomized double-blind trial. The study involved 51 patients with life-threatening diagnoses who received either a low or high dose of psilocybin in a cross-over design. Significant reductions in depression and anxiety, coupled with increased life meaning and optimism, were observed following high-dose psilocybin administration. These effects were sustained at the 6-month follow-up, suggesting the therapeutic potential of psilocybin in alleviating psychological distress in cancer patients. Mitchell, J. M., Bogenschutz, M., Lilienstein, A., Harrison, C., Kleiman, S., Parker-Guilbert, K., Ot’alora G, M., Garas, W., Paleos, C., Gorman, I., Nicholas, C., Mithoefer, M., Carlin, S., Poulter, B., Mithoefer, A., Quevedo, S., Wells, G., Klaire, S. S., van der Kolk, B., Tzarfaty, K., … Doblin, R. (2021). MDMA-assisted therapy for severe PTSD: A randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine, 27(6), 1025–1033. https://doi.org/10.1038/s41591-021-01336-3

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Mitchell et al. (2021) conducted a phase 3 trial to assess the efficacy and safety of MDMA-assisted therapy for severe PTSD. Ninety participants were randomized to receive either MDMA therapy or a placebo, alongside preparatory and integrative sessions. Significant reductions in PTSD symptoms were observed in the MDMA group compared to the placebo, with some patients achieving remission after just one or two sessions. This study highlights the promising therapeutic potential of MDMA-assisted therapy in individuals with severe PTSD, warranting further clinical evaluation.

ADDITIONAL INSTRUCTIONS FOR THE CLASS – PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

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• Discussion Questions (DQ)

Initial responses to the DQ should address all components of the questions asked, including a minimum of one scholarly source, and be at least 250 words. Successful responses are substantive (i.e., add something new to the discussion, engage others in the discussion, well-developed idea) and include at least one scholarly source. One or two-sentence responses, simple statements of agreement or “good post,” and responses that are off-topic will not count as substantive. Substantive responses should be at least 150 words. I encourage you to incorporate the readings from the week (as applicable) into your responses.

• Weekly Participation

Your initial responses to the mandatory DQ do not count toward participation and are graded separately. In addition to the DQ responses, you must post at least one reply to peers (or me) on three separate days, for a total of three replies. Participation posts do not require a scholarly source/citation (unless you cite someone else’s work). Part of your weekly participation includes viewing the weekly announcement and attesting to watching it in the comments. These announcements are made to ensure you understand everything that is due during the week.

• APA Format and Writing Quality

Familiarize yourself with the APA format and practice using it correctly. It is used for most writing assignments for your degree. Visit the Writing Center in the Student Success Center, under the Resources tab in Loud-cloud for APA paper templates, citation examples, tips, etc. Points will be deducted for poor use of APA format or absence of APA format (if required). Cite all sources of information! When in doubt, cite the source. Paraphrasing also requires a citation. I highly recommend using the APA Publication Manual, 6th edition.

• Use of Direct Quotes

I discourage over-utilization of direct quotes in DQs and assignments at the Master’s level and deduct points accordingly. As Masters’ level students, it is important that you be able to critically analyze and interpret information from journal articles and other resources. Simply restating someone else’s words does not demonstrate an understanding of the content or critical analysis of the content. It is best to paraphrase content and cite your source.

• LopesWrite Policy

For assignments that need to be submitted to Lopes Write, please be sure you have received your report and Similarity Index (SI) percentage BEFORE you do a “final submit” to me. Once you have received your report, please review it. This report will show you grammatical, punctuation, and spelling errors that can easily be fixed. Take the extra few minutes to review instead of getting counted off for these mistakes. Review your similarities. Did you forget to cite something? Did you not paraphrase well enough? Is your paper made up of someone else’s thoughts more than your own? Visit the Writing Center in the Student Success Center, under the Resources tab in Loud-cloud for tips on improving your paper and SI score.

• Late Policy

The university’s policy on late assignments is a 10% penalty PER DAY LATE. This also applies to late DQ replies. Please communicate with me if you anticipate having to submit an assignment late. I am happy to be flexible, with advance notice. We may be able to work out an extension based on extenuating circumstances. If you do not communicate with me before submitting an assignment late, the GCU late policy will be in effect. I do not accept assignments that are two or more weeks late unless we have worked out an extension. As per policy, no assignments are accepted after the last day of class. Any assignment submitted after midnight on the last day of class will not be accepted for grading. PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

• Communication

Communication is so very important. There are multiple ways to communicate with me: Questions to Instructor Forum: This is a great place to ask course content or assignment questions. If you have a question, there is a good chance one of your peers does as well. This is a public forum for the class. Individual Forum: This is a private forum to ask me questions or send me messages. This will be checked at least once every 24 hours.

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